In total, 104 kinds of naturally active compounds can be extracted from hemp, the most important of which are CBD and THC. But what makes them different, and why are they so popular? Both are active chemicals that act on human receptors, but CBD and THC are different in many ways.

THC can cause feelings like paranoia and hallucinations, while CBD has no such psychoactive effects.

This article answers all your questions about what is CBD?, what is THC?, a detailed study on CBD vs. THC to make our content more presentable we have prepared a CBD vs. THC Chart showing different CBD effects and THC effects on the body and brain, and comprehensively proposed CBD vs. THC differences.

What Is CBD?

Cannabidiol (CBD) is a natural extract that has significant effects on many diseases. CBD also reduces the psychoactive effects of THC, which contributes to the medical benefits of THC because large doses of THC are known to cause feelings of paranoia and anxiety.

Scientific research has found that CBD and other ingredients are the main ones that play a role. A particular system in the human body is called the endocannabinoid system, which regulates processes like controlling sleep, appetite, and the immune system.

The cannabinoids naturally secreted in the human body will react with the human nervous system. By acting with cannabinoid receptors, CBD can reduce inflammation and chronic pain.

What Is THC?

Tetrahydrocannabinol is the most abundant cannabinoid (an active compound unique to cannabis) found in the cannabis plant. The THC of most plants is found in trichomes, which are present on the flowers of fully mature female plants.

This compound is found only in cannabis plants. It serves as a defense mechanism to protect plants from various predators, bacteria, parasites, and solar radiation.

Adult male plants also contain THC, but the amount is negligible, so to have the full potential effect of THC, fully developed female plants must be used.

THC works in our body by interacting with our internal endocannabinoid system. This will produce a wide range of psychoactive and medicinal effects.

Tetrahydrocannabinol was discovered in 1964 by Dr. Raphael Mechoulam, an Israeli organic chemist. The famous chemist also made some other valuable contributions to cannabis science, such as the discovery of the endocannabinoid system and the isolation of CBD.


THC and CBD are just two of dozens of active compounds in cannabis. Tetrahydrocannabinol is famous for its psychoactive properties. It is this compound that helps produce the high content associated with cannabis use.
Both CBD and THC have unique health benefits. CBD products can have a certain amount of THC, but according to the law, its concentration must be less than 0.3%.

Unlike THC, cannabidiol does not produce any mental effects and is entirely non-psychoactive.

THC produces its effects by binding to the receptors of our endocannabinoid system. Once these receptors are affected by THC, they notify other parts of the ECS to perform various chemical tasks in the body.

On the other hand, CBD has a different approach. It limits the fatty acid amide hydrolase (FAAH), which is responsible for destroying our internal endocannabinoids, and then increasing the number of our endocannabinoids. Following, we have presented various points of CBD vs. THC.

Chemical Structure

CBD vs THCCBD cannabis is a phenolic compound found in marijuana and marijuana plants in the genus Cannabis formula C21H30O2, with a molecular weight of 314.469g / mol. CBD is a phytocannabinoid and a plant metabolite. The molecular structure of CBD includes the presence of hydroxyl groups.

Tetrahydrocannabinol is a phytocannabinoid produced in plants Cannabis genus. With the same chemical formula, C19H26O2, and has a molecular weight of 314.469 g/mol.

However, the molecular structure of THC includes the presence of a ring.

  • CBD and THC are plant cannabinoids present in cannabis plants; they have the same molecular formula and slightly different atoms’ arrangements.
  •  THC and CBD also bind to different receptors and have different effects on the human body.
  • CBD is not psychoactive and helps to stop the effects of THC by preventing the binding of THC to CB1.
  • THC is a chemical that causes people to become “high,” but it does have some health benefits.

Effect On Body And Brain

Cannabis has long been used in medical treatment. Cannabis plant extracts have many essential effects on treating neurological disorders like anxiety, depression, stress, and insomnia.

CBD is not a psychoactive substance, and its effect on cerebral circulation is entirely different from THC. Cannabinoids work by binding to specific receptors in brain tissue. These receptors are called cannabinoid receptors.

These receptors directly affect the cell function they are in, and the psychological effects begin quickly. Studies have shown that the difference between cannabidiol (CBD) and tetrahydrocannabinol is how differently it affects the human brain.

Effects of CBD

Many studies and controlled clinical trials have proven that CBD can be used as an antipsychotic drug for its tolerability, safety, and effectiveness. The mechanism by which CBD can be used to prevent traumatic brain injury lies in the extensive anti-inflammatory properties of CBD.

As mentioned earlier, CBD is not a hallucinogen, so it prevents the brain from moving in the direction of euphoric emotions. CBD can even block the psychoactive effects of THC and eliminate the effect by giving it a highly controllable therapeutic effect. Due to its antipsychotic effects, one can use it for many medical purposes.

Effects of THC

Psychedelic cannabinoids such as THC can cause euphoria, increased sensation, increased heart rhythm, decreased painful stimulation, and difficulty concentrating on specific tasks.

  • Hippocampus- Located in the temporal lobe of the brain, responsible for the formation of memories. The effect of THC on the hippocampus can affect short-term memory.
  • Frontal Cortex- The cannabinoid receptors in this part of the brain that our thinking process takes place can regulate our thinking patterns. THC makes neurons faster than usual, which leads to more ideas that are closely related to creativity.
  •  Cerebellum- This is responsible for movement and general coordination. THC affects the cerebrum in such a way, making us feel high, which is why we tend to seem a little clumsy and uncoordinated.
    When the surge of THC reaches the brain, dopamine levels soar, making us feel happy, contented, and euphoric.

Due to the unique personal chemistry of each person, the intensity of these effects may differ in each person.

Health Benefits Of CBD

If you look at the health benefits of CBD, you will find a very, very long list. All over the world, people are using CBD to treat many diseases, such as anxiety, chronic pain, epilepsy, arthritis, headaches, post-traumatic stress disorder, etc.

  • CBD Treats Alzheimer And Other Forms Of Dementia:
    Alzheimer’s disease is a condition that occurs due to the gradual destruction and death of cortical cells, and the death of these cells causes dementia in patients.
    There is currently no cure for Alzheimer’s, but CBD has shown great potential to cure Alzheimer’s. Therefore, cannabinoids such as CBD can effectively regulate brain cells in the nervous system and can treat various types of dementia, including Alzheimer’s disease.
  •  Reduce Inflammation And Protect Brain Cells:
    Research has proved that CBD can prevent free radical damage, reduce inflammation and protect brain cells. Studies have shown the endocannabinoid system’s role in simulating neurogenesis, which is the scientific method of “cultivating new brain cells.”
  • Relieve Anxiety And Depression:
    CBD has anti-anxiety and depression effects because it can be related to the effects of serotonin in the human body, and serotonin is a neurotransmitter that controls mood and social behavior.
    People use CBD essential oil to treat insomnia and anxiety, people who use CBD oil to treat their stress disorders and swear by the benefits of CBD.
  •  Neuroprotection:
    Researchers have discovered that CBD can interact with the body’s endocannabinoid system and other brain signaling systems. It also has a positive effect on patients with neurological disorders. There has been a large number of studies on the use of CBD to treat epilepsy and multiple sclerosis. In particular, drugs for the treatment of epilepsy are developed and approved by the FDA.

Other Benefits Are

People usually use CBD to help treat the following problems:

  • Inflammatory bowel disease
  • Seizures
  • Mental illness or mental disorder
  • Migraine

In a group of 47 patients with multiple sclerosis in a clinical study, patients who took CBD drugs for one month experienced significant improvements in pain, walking ability, and muscle cramps.

In another clinical study of 58 patients with rheumatoid arthritis, patients taking CBD have greatly reduced pain during exercise and rest, and their sleep quality has also been significantly improved.

Health Benefits Of THC

THC can help treat an alarming number of symptoms of diseases and health conditions.

  • Fight Cancer Cells
    Perhaps the most surprising use of THC is to fight cancer cells. Animal clinical trials have shown that THC compounds cause cancer cell autophagy (or cell suicide), thereby preventing the proliferation and growth of certain tumors.
    In addition, the anti-inflammatory properties of THC make this natural chemical a powerful assistant for a large number of autoimmune diseases, states of depression, and fights against neurodegenerative disease.

THC has potential use in the treatment of some of the following:

  • glaucoma
  • Muscle cramp
  • loss of appetite
  • insomnia

CBD and THC have similar effects in the treatment of medical diseases. However, the purpose of each substance is different, and so the topic of CBD vs. THC is always in the hype.

Aroma and Appearance

CBD and THC are parts of the same plant but, at the same time, have numerous differences. At a glance, they may look similar, but they have different colors, textures, and aroma.
The THC leaves are in the dark green shade, and when dried, they look more of a darker blue, and these plants are much taller and may reach up to 20-25 feet. THC leaves have a strong and pungent aroma, and many people find them unpleasant for the first time. Even its aroma may make you feel a little paranoid.
Whereas the leaves of the CBD plant have a bright green shade, the leaves are smaller than in the THC plant. CBD leaves are bulkier than THC leaves, and CBD plants can only be up to 5-6 feet. CBD plants have a very earthy and nutty fragrance. Many people feel that it smells like wheatgrass.

Below We Have Presented A CBD vs. THC Chart to Make Their Differences More Presentable


Makes you high or paranoid

  • No
  • Yes

They are illegal

  • No
  • Yes

Can have side effects

  • It may have some common side effects
  • Has Psychoactive side effects

It may increase your appetite

  • No
  • Yes

Helps with depression

  • Yes
  • No

Plant height

  • 5-6 feets
  • 20-25 feets

Helps with anxiety

  • Yes, has long-term effects of reducing anxiety
  • Yes, has short-term effects of reducing anxiety.

Interaction with the endocannabinoid system

  • Yes
  • Yes

Famous name

  • Indica
  • Sativa

Can appear on a drug test

  • It may appear, but using it for medicinal purposes is legal
  • It will appear on a drug test, and it’s still not legal for even medicinal purposes

Effects of long-term use

  • relief from inflammation, convulsions, anxiety
  • Helps with insomnia, altered senses of hearing, smell, and taste

Side Effects Of THC

People taking THC may experience some temporary side effects. These can include:

  • Dry mouth
  • Red eyes
  • Slower than the average response time
  • Overall feeling very high
  • Memory loss
  • Coordination problem
  • Rapid heartbeat

According to some studies, regular or high-dose THC can increase the risk of schizophrenia in some people who are prone to schizophrenia.

Side Effects Of CBD

It is not surprising to have mild side effects after consuming CBD products. Because even if CBD does not make you high, it is related to your body’s endocannabinoid system and can regulate numerous process receptor interactions for first-time users. Following are some side effects seen after consuming CBD products:

● Fatigue
● Diarrhea
● Appetite and weight changes
● Feeling nauseated
● Dry Mouth
● Headache

Neither CBD nor THC has any deadly side effects. It will not be fatal if taken correctly. Similarly, people who use THC recreationally seem to be rarely at risk of addiction.

CBD Vs. THC- Issue Of Legalization

The FDA only approved one CBD product, Epidiolex, for two rare forms of epilepsy, and evidence on how CBD affects the human body is still limited.

From a legal perspective, the medicated CBD is legal in many countries. As many CBD products have proved to treat various kinds of diseases, like CBD anxiety, stress, and depression, but only two tests are taken before making the CBD completely legal, first, the levels of THC should be less than 0.3 %, and second, the CBD should be extracted from the Hemp seeds.

CBD and THC are still federally illegal substances and are only approved for pharmaceutical or recreational use in certain states.

Legalization According To The Farm Bill Of 2018

The 2018 Farm Bill, using THC was completely illegal, but now it is only limited to 0.3% THC in various products.
In the case of THC, very few countries allow the use of THC products in the case of medicinal purposes, and it’s not legal to sell these products over the counter. Both THC and CBD have medical value. It is just that THC has too great of a cognitive impact on ordinary people.

Due to the outstanding contribution of CBD in medical treatment, society and the government have to re-examine cannabis, and some places even legalize cannabis or at least legalize medical cannabis.

Laws regarding the use of medical and recreational marijuana are changing rapidly. People considering using CBD or THC should check local laws regularly as they may change or are changing.

The Bottom Line

Both CBD and THC have tremendous benefits to treat pain, nausea, sleep apnea, or stress disorders, as well as anti-chemotherapy, symptoms, or side effects of multiple sclerosis, glaucoma, AIDS, or spinal injury. Both of them are some of the greatest gifts of nature and have excellent healing potential yet to be explored.
Although CBD vs. THC is always hype, combining these two cannabinoids is fantastic for treating diseases and health conditions because they have a perfect relationship.
They enter the endocannabinoid system through different pathways, they all have their unique beneficial effects, but they can also cooperate very well to maximize their therapeutic potential.